Periwell
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Evidence Level: Moderate

Magnesium Glycinate

Targeted For:Sleep DisruptionAnxietyMuscle Aches

Clinical Trial Results

Multiple trials showing subjective improvement in insomnia severity and sleep onset latency in midlife women. Does not directly affect estrogen production.

Biological Mechanism

Magnesium binds to and stimulates GABA receptors (the brain's calming neurotransmitters) while inhibiting NMDA receptors. The glycinate form includes the amino acid glycine, which itself promotes sleep and lowers core body temperature.

Known Risks & Side Effects

  • • Mild GI upset (though glycinate is the most tolerable form)
  • • Safe at recommended doses (300-400mg)

Medication Interactions

  • • Bisphosphonates
  • • Certain antibiotics (tetracyclines)

Does it work for you?

Start tracking Magnesium Glycinate in Periwell today. In 30 days, your Health Report will show you exactly if your symptoms improved or if you are experiencing the placebo effect.

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