Our Clinical Methodology
Periwell is engineered using validated clinical staging systems, symptom scales, and peer-reviewed research. Here is exactly how we generate objective data — with references.
Diagnostic & Staging Frameworks
STRAW+10 Staging System
Harlow et al. (2012), Menopause, 19(4):387-395The Stages of Reproductive Aging Workshop (STRAW) +10 framework is the gold standard used by clinicians worldwide to evaluate the onset of perimenopause and menopause.
- We utilize STRAW+10 criteria to analyze bleeding patterns and track the transition through early and late perimenopause.
- This allows Periwell to map symptom emergence strictly against objective clinical timelines rather than relying on unreliable FSH testing.
Menopause Rating Scale (MRS)
Heinemann et al. (2004), Health and Quality of Life OutcomesThe MRS is a validated patient-reported outcome measure used to quantify the burden of menopausal symptoms on health-related quality of life across three subscales.
- Somatic subscale: Hot flushes, heart discomfort, sleep problems, joint and muscular discomfort.
- Psychological subscale: Depressive mood, irritability, anxiety, physical and mental exhaustion.
- Urogenital subscale: Sexual problems, bladder problems, dryness of vagina.
Greene Climacteric Scale
Greene (1998), Maturitas, 29(1):25-31A 21-item standardized scale used to evaluate the range and severity of perimenopause symptoms, producing a standard measure of psychological, somatic, and vasomotor distress.
- Validated in independent clinical studies across multiple countries.
- Provides a comparable numerical score that can be tracked over time to measure therapeutic efficacy.
Regulatory & Wellness Classification
Periwell is a General Wellness App — Not a Medical Device
Periwell is classified as a general wellness application under FDA and CE guidance. It is designed to help users log, track, and understand their perimenopause symptoms — it does not diagnose, treat, or prescribe. All clinical reports are intended to facilitate informed conversations with your healthcare provider, not replace professional medical assessment.
Clinical Society Alignment
Periwell's data architecture, evidence summaries, and patient reports are aligned with the treatment guidelines published by the world's leading bodies in reproductive endocrinology:
The Menopause Society
Aligned with the 2024 Hormone Therapy Position Statement.
View guidelines →British Menopause Society
Conforming to NICE guidelines regarding HRT access and care.
View guidelines →Endocrine Society
Referencing clinical practice guidelines for the treatment of symptoms.
View guidelines →How Periwell Uses AI
Periwell uses a rule-based clinical scoring engine — not a black-box AI model — to compute validated scale scores (MRS, Greene) from your symptom logs. Pattern detection (e.g. sleep vs. cycle correlation) uses statistical analysis of your longitudinal data.
Rule-based scoring
Validated scales computed deterministically from your inputs — no generative AI.
Statistical correlations
Time-series analysis of your own data, never pooled or shared with others.
No training on your data
Your health logs are used only to generate your personal reports.
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