Periwell
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Evidence Level: Moderate

Black Cohosh

Actaea racemosa

Targeted For:Hot FlashesNight Sweats

Clinical Trial Results

Highly mixed data. Cochrane reviews found insufficient evidence of efficacy over placebo, but specific standardized extracts (like Remifemin) have shown 20-30% reductions in vasomotor symptoms in some European trials.

Biological Mechanism

Historically thought to be a phytoestrogen, modern research suggests it does not bind to estrogen receptors. Instead, it appears to bind to serotonin receptors in the hypothalamus, partially regulating the body's 'thermostat' disrupted by estrogen decline.

Known Risks & Side Effects

  • • Rare but severe hepatotoxicity (liver damage)
  • • Should not be used longer than 6 months without medical supervision

Medication Interactions

  • • Statins (potentially)
  • • Any hepatotoxic medications

Does it work for you?

Start tracking Black Cohosh in Periwell today. In 30 days, your Health Report will show you exactly if your symptoms improved or if you are experiencing the placebo effect.

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