Periwell
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Evidence Level: Limited

Ashwagandha

Withania somnifera

Targeted For:StressFatigueBrain Fog

Clinical Trial Results

Solid evidence for general stress reduction in healthy adults. Specific perimenopause efficacy is underexplored, though one 2021 study showed mild improvements in Greene Climacteric Scale scores.

Biological Mechanism

An adaptogen that blunts the HPA axis response to stress, lowering cortical cortisol secretion. For perimenopausal women experiencing heightened anxiety due to progesterone withdrawal, limiting cortisol load can improve threshold tolerance.

Known Risks & Side Effects

  • • May increase thyroid hormone levels (caution in hyperthyroidism)
  • • Can cause drowsiness

Medication Interactions

  • • Immunosuppressants
  • • Thyroid medications
  • • Sedatives

Does it work for you?

Start tracking Ashwagandha in Periwell today. In 30 days, your Health Report will show you exactly if your symptoms improved or if you are experiencing the placebo effect.

Track Efficacy in Periwell